The function of individual metabolites is also highlighted. These transient bioactive metabolites allow cells to respond to the external environment to maintain cellular health. Cellular lipids are metabolised by phospholipases, lipid kinases and phosphatases to make new bioactive metabolites. Lipid synthesis is intimately connected to their transport within cells the contribution by proteins that transport lipids, lipid transport proteins will be described. The fatty acids (FAs) are the main building blocks of lipids and contribute to the diversity. This review summarises the biosynthesis of the lipids of the mammalian cell phospholipids, sphingolipids and cholesterol and how lipid diversity is achieved. Understanding lipid diversity, their synthesis and metabolism to generate signalling molecules will provide insight into the fundamental function of the cell.

Lipids regulate many physiological functions of cells and alterations in membrane lipid metabolism are associated with major diseases including cancer, Type II diabetes, cardiovascular disease and immune disorders.

Once regarded merely as structural components, lipids have taken centre stage with the discovery of their roles in cell signalling and in the generation of bioactive metabolites. Lipids are essential constituents of cellular membranes.

Free download structure of lipids